99% Adapalene Powder CAS 106685-40-9 for Gel

• CAS No.: 106685-40-9
• Formula: C28h28o3
• EINECS: /
• Type: Pharmaceutical Intermediates
• Appearance: Powder
• Quality: Refined
• Model NO.: /
• Colour: White
• Product Name: Adapalene
• Grade Standard: Medicine/Cosmetic Grade
• Storage: Cool and Dry Place
• Transport Package: 1kg/Bag; 25kg/Drum
• Specification: 99%
• Trademark: JULY
• Origin: China
• HS Code: 2918990090
• Production Capacity: 5000kg/Month

Product Description

Product Description

Adapalene is a second-generation topical retinoid primarily used in the treatment of mild-moderate acne, and is also used
off-label to treat keratosis pilaris as well as other skin conditions. It is effective against acne conditions where comedones are predominant.

Adapalene, also known as 6 - [3 - (1-adamantyl) - 4-methoxyphenyl] - 2-naphthoic acid, has a molecular formula of c28h28o3. It is white or almost white powder at room temperature, insoluble in water or ethanol, slightly soluble in . Adapalene is used in dermatology. It is suitable for the skin treatment of acne vulgaris with acne, papule and pustule as the main manifestations. It can also be used to treat acne on the face, chest and back.

 

Adapalene is a retinoid, in vivo and in vitro models of inflammation were demonstrated to have anti-inflammatory properties.Stable chemical structure of adapalene, in the air and light without decomposing. Mechanism and adapalene with and specific nuclear retinoic acid receptor combined with retinoic acid is the combination of adapalene and protein and binding of cytoplasmic receptors.

In mice to establish animal model of skin drug test proved that adapalene can treat acne, and acne vulgaris and differentiation process as a role. The mechanism of adapalene is considered by the hair follicle epithelium of normal cell differentiation and reduce microcomedo formation.

Product Name	Adapalene
Other name	Adapalene Powder
Appearance	White Powder
Grade	Cosmetic/Medicine grade
CAS	106685-40-9
MF	C28H28O3
Specification	99%
Storage	Keep in cool & dry place, stay away from strong light and heat
Shelf Life	24 months

 

Function

 

1.Adapalene, a new retinol drug, is a Naphthalic acid derivative of all aromatic acids, belonging to the third generation of retinoids. Like other topical retinoids (RA), adapalene has a wide range of pharmacological activities, including anti-inflammatory, anti proliferative and so on

 

2.Adapalene can regulate the differentiation of normal human keratinocytes. Adapalene was 3 times stronger than RA in inhibiting the differentiation of F9 cells. In addition, adapalene increased the production of neuraminidase by keratinocytes, thus increasing the barrier function within the infundibulum of hair follicles.

 

3.Adapalene has a strong inhibitory effect on the proliferation of HeLa cells. The differentiated cells from cervical cancer have high proliferative activity and have been routinely used to study the antiproliferative effects of retinoids.

 

4.Adapalene inhibits the oxidative metabolism of arachidonic acid mainly by inhibiting 5-lipoxygenase and 15 lipoxygenase pathway in human polymorphonuclear leukocytes, thus inhibiting the chemotaxis of human peripheral blood neutrophils.

 

5.Adapalene has unique chemical stability, high stability to light and oxidants, and high lipophilicity, which is easy to pass through hair follicles.

 

6.Adapalene is a kind of microcrystalline suspension in structure. The particle diameter of adapalene is 3-10 ixm, which makes the drug more residual in epidermis, less absorption in dermis, and lower systemic side effects.

 

7.There are many reports about the topical use of adapalene in the treatment of other keratosis and pigmentation disorders, including peritrichoderma, Darier's disease, verruca plana, melanosis of hair follicle, solar keratosis and some light damaged skin diseases.

Application

1.Applied in pharmaceutical field

2.Applied in Cosmetic product field

 

Packaging & Shipping

Packing	1kg/bag ,25kg/bag;25kg/drum; according to your requirements
Transit	Fedex, TNT,DHL,EMS,and so on.
Port	Shanghai/Tianjin/Dalian/Beijing/Xi'an
Lead Time	3-5 working days upon received the payment
For mass orders, it will be delivered by air or sea. Depending on your location, please allow 1-5 business days for your order to arrive. For small order, please expect 3-7 days by UPS DHL EMS. For mass order, please allow 5-8 days by Air, 15-30 days by Sea.

 

Company Profile

Hefei Joye import export Co.,ltd is trading system gradually mature stable, scale, expanding opening flexible, the godfather management, Its marketing network, good business reputation has been praised by customers. The company has already established marketing channels with many manufactures and customers all over the world.

We are specialized in Chemical raw materials: API, Pharmaceutical intermediates, Plant extracts, Health care ingredient, Vitamin,Food additives and Cosmetic additives. These products are widely used in pharmaceutical industry, chemical industry, food industry and other industries. Welcome to consult us. Our products are widely recognized and trusted by users and can meet continuously developing economic and social needs. We welcome new and old customers from all walks of life to contact us for future business relationships and achieving mutual success!

FAQ

 

1. What's the MOQ?
Usually1kg. It is based on the different product. Some are lg and some are 1 ton. Please be free to consult our salesman.
2. What's the shipping time?
If in stock, we will ship it out immediately. By FedEx will be 3~5 days to you.
3. If I need less than the MOQ, is it possible?
 Yes. Please be free to consult our salesman.
4. Can you supply the free sample?
Usually it is possible. but the shipping cost be paid bycustomers. It based on the differentproduct.Please be free to consult our salesman.
5. How to store the product?
 Store in cool and dry place. It must be in well closed containers. The shelf life will be 2 years.
6. What's your main payment method?
T/T, trade assurance, west union, money gram.
7: Do you have COA, MSDS, co, Health certificate, form 9 or other certificate?
 Yes, we have. pls be free to contact us to get updated one.