| CAS No.: | 97540-22-2 |
|---|---|
| Formula: | 97540-22-2 |
| EINECS: | 97540-22-2 |
| Type: | Pharmaceutical Intermediates |
| Appearance: | Powder |
| Quality: | Industrial |
| Samples: |
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| Customization: |
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S-Adenosyl-L-methionine Disulfate Tosylate
CAS NO.:97540-22-2
Assay:95.0%-103%
Ademethionine Disulfate Tosylate (SAMe for short) is a common cosubstrate involved in methyl group transfers.
SAMe was first discovered in Italy by G. L. Cantoni in 1952, can preventing liver cancer, promoting cartilaginous tissue forming and concrescence, may help fight depression, alzheimer's disease, liver disease, and the pain of osteoarthritis.
Ademetionine disulfate tosylate is now universerally acknowleged as an important pharmaceuticals to treat liver diseases. Nowaday it is commonly used in pharmaceuticals, health care food industry both at domestic and international market.
1. S-Adenosyl methionine (SAM, SAMe, SAM-e) is a coenzyme involved in methyl group transfers. It is made from
adenosine triphosphate (ATP) and methionine by methionine adenosyltransferase (EC 2.5.1.6). Transmethylation,
transsulfuration, and aminopropylation are the metabolic pathways that use SAM. Although these anabolic reactions
occur throughout the body, most SAM is produced and consumed in the liver.
2 .The methyl group (CH3) attached to the methionine sulfur atom in SAM is chemically reactive. This allows donation
of this group to an acceptor substrate in transmethylation reactions. More than 40 metabolic reactions involve the
transfer of a methyl group from SAM to various substrates such as nucleic acids, proteins, and lipids.
3 .In bacteria, SAM is bound by the SAM riboswitch, which regulates genes involved in methionine or cysteine biosynthesis.
4 .Another major role of SAM is in polyamine biosynthesis. Here, SAM is decarboxylated by adenosylmethionine
decarboxylase (EC 4.1.1.50) to form S-adenosyl-5'-3-methylpropylamine.
5 .SAM is required for cellular growth and repair. It is also involved in the biosynthesis of several hormones and
neurotransmitters that affect mood, such as dopamine and serotonin. Methyltransferases are also responsible for
the addition of methyl groups to the 2' hydroxyls of the first and second nucleotides next to the 5' cap in messenger RNA.
6 .In the United States, SAM is sold as a nutritional supplement under the marketing name SAM-e (also spelled
SAME or SAMe). Some research has indicated that taking SAM on a regular basis help fight depression, liver
disease, and the pain of osteoarthritis. Multiple clinical trials indicate benefits for depression, some liver conditions
and osteoarthritis. All other indications are not yet proven.
| Packing | 1kg/aluminum foil bag ,5kg/aluminum foil bag;25kg/drum; according to your requirements |
| Transit | Fedex, TNT,DHL,EMS,and so on. |
| Port | Shanghai/Tianjin/Dalian/Beijing/Xi'an |
| Lead Time | 3-5 working days upon received the payment |
| For mass orders, it will be delivered by air or sea. Depending on your location, please allow 1-5 business days for your order to arrive. For small order, please expect 3-7 days by UPS DHL EMS. For mass order, please allow 5-8 days by Air, 15-30 days by Sea. |
Hefei JOYE Import & Export CO.,LTD is a import and export trade company established in 2011.Approved by the Chinese government set up trade enterprises.The Customs Registration code of the company is 3401961603.
We are specialized in Chemical raw materials: API, Pharmaceutical intermediates, Plant extracts, Health care ingredient, Vitamin,Food additives and Cosmetic additives. These products are widely used in pharmaceutical industry, chemical industry, food industry and other industries. Welcome to consult us. Our products are widely recognized and trusted by users and can meet continuously developing economic and social needs. We welcome new and old customers from all walks of life to contact us for future business relationships and achieving mutual success!
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FAQ
1.What's the min order for the usual?
15kg. As for the high-value products, min order starts from 1g or 10g.
2.What's the sample cost?
Free samples for normal products. Will charge on high-value products like huperzine-A.
3.What's the package and payment terms?
We pack with 2 layers of food-grade plastic bags inside and aluminum foil bag outside, 10-25kg/drum.
And payment terms are normally T/T & Western Union.
4.What's the shipping time?
May take 3-5 working days to Asia or surrounding countries by EMS etc..
5~10 working days to European or Americ countries by EMS etc..
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