| Character: | White Powder |
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| Package: | 1kg/Aluminum Foil Bag |
| Test: | HPLC |
| Name: | Terbinafine |
| CAS: | 78628-80-5 |
| Transport Package: | Drum/Tin |
| Samples: |
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| Customization: |
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Audited Supplier Antineoplastic Terbinafine HCl Powder CAS 78628-80-5 Terbinafine Hydrochloride
| Terbinafine Hydrochloride Basic information | |
| Product Name: | Terbinafine Hydrochloride |
| CAS: | 78628-80-5 |
| MF: | C21H26ClN |
| EINECS: | 616-640-4 |
| Terbinafine Hydrochloride Chemical Properties | |
| Melting point | 204-208°C |
| storage temp. | -20°C Freezer |
| solubility | methan: soluble50mg/mL |
| form | powder |
| color | white |
| Merck | 149,156 |
| CAS DataBase Reference | 78628-80-5(CAS DataBase Reference) |
Terbinafine Hydrochloride spec:
| Items | Specifications | Results |
| Appearance | White or almost white powder | White powder |
| Solubility | Practically insoluble in water and in aceto, soluble in ethan and in methan | Complies |
| A: IR | The infrared absorption spectrum exhibits maximum only at the same wavelengths as that of the standard sample | Complies |
| B: | It gives reaction of chlorides | Complies |
| Impurity A NMT 0.1% | 0.00% | |
| Impurity B NMT 0.1% | 0.01% | |
| Impurity C NMT 0.1% | 0.02% | |
| Impurity D NMT 0.1% | 0.02% | |
| Any other impurity NMT0.1% | 0.05% | |
| Total of impurity NMT 0.3% | 0.15% | |
| Loss on drying | NMT0.5% | 0.15% |
| Sulphated ash | NMT0.1% | 0.02% |
| Assay | 99%~101% (dried substance ) | 99.85% |
Terbinafine hydrochloride a synthetic allyla antifungal. It is highly lipophilic in nature and tends to accumulate in skin, nails, and fatty tissues.
Terbinafine·HCl a member of the allyl class of antifungals, has been found to be a specific inhibitor of ergosterol synthesis via squalene epoxidase inhibition. Squalene epoxidase is an enzyme released by the dermatophyte fungi to break down Squalene, which interferes with cell membrane function and wall synthesis.
Terbinafine hydrochloride is a white fine crystalline powder that is freely soluble in methan and dichlorome, soluble in ethanol, and slightly soluble in water. Like other allylamines, terbinafine inhibits ergosterol synthesis by inhibiting squalene epoxidase, an enzyme that is part of the fungal cell membrane synthesis pathway. Because terbinafine prevents conversion ofsqualene to lanosterol, ergosterol cannot be synthesized. This is thought to change cell membrane permeability, causing fungal cell lysis.
1. Terbinafine Hcl is mainly effective on the dermatophyte group of fungi.
2. As a 1% cream or powder, it is used topically for superficial skin infections such as jock itch (tinea cruris), athlete's foot (tinea pedis), and other types of ringworm (tinea corporis). Terbinafine cream works in about half the time required by other antifungals.
3. Oral 250mg tablets are often prescribed for the treatment of onychomycosis, a fungal nail infection, typically by a dermatophyte or Candida species. Fungal nail infections are located deep under the nail in the cuticle to which topically applied treatments are unable to penetrate in sufficient amounts. The tablets may, rarely, cause hepatotoxicity, so patients are warned of this and may be monitored with liver function tests. Alternatives to oral administration have been studied.
4. Terbinafine may induce or exacerbate subacute cutaneous lupus erythematosus. Persons with lupus erythematosus should first discuss possible risks with their doctor before initiation of therapy.
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Package
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1kg/bag ,25kg/bag;25kg/drum; customize as customer's equirements.
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Transit
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Fedex, TNT,DHL,EMS,and so on.
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Shipping port
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Shanghai/Tianjin/Dalian/Beijing/Xi'an
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Lead Time
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1-2 working days upon received the payment
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For mass orders, it will be delivered by air or sea. Depending on your location, please allow 1-5 business days for your order to arrive. For small order, please expect 3-7 days by UPS DHL EMS. For mass order, please allow 5-8 days by Air, 15-30 days by Sea. |
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Service:
1. Any inquiries will be replied within 12 hours.
2. Dedication to quality, supply & service.
3. Strictly on selecting raw materials.
4. OEM/ODM Available.
5. Reasonable & competitive price, fast lead time.
6. Sample is available for your evaluation & formulation development.
Advantages:
1. Faster delivery: Sample order in stock and 3-7 days for bulk production.
2. We have strong cooperation with DHL, TNT, UPS, FEDEX, EMS. Or you also can choose your own shipping forwarder.
3. After-Sale Service:
1)International Authorized Third-Party Test For The Products You Demand.
2)60 Days Warranty of quality of goods.
Hefei JOYE Import & Export CO.,LTD is a import and export trade company established in 2011.Approved by the Chinese government set up trade enterprises.The Customs Registration code of the company is 3401961603.
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