| Character: | White Powder |
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| Package: | 1kg/Aluminum Foil Bag |
| Test: | HPLC |
| Name: | Ibrutinib |
| CAS: | 936563-96-1 |
| Function: | Anti-Cancer |
| Samples: |
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| Customization: |
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Suppliers with verified business licenses
Audited Supplier Pharmaceutical Raw Material Ibrutinib Powder in Bulk CAS 936563-96-1
| Product name |
Ibrutinib |
| CAS NO. | 936563-96-1 |
| Synonyms |
Ibrutinib |
| Category | Pharmaceutical Raw Materials, Active Pharmaceutical Ingredients, Bulk Drugs, Fine Chemicals. |
| Purity | 99% Ibrutinib |
| Appearance | Ibrutinib powder |
| Shelf life | 2 years |
| Usage |
Ibrutinib is an anticancer drug targeting B-cell malignancies. |
| Storage | Ibrutinib should be stored in a well-closed container at low temperature, keep away from moisture, heat, and light. |
| Note | Ibrutinib for R&D use only. |
Ibrutinib is a highly selective Bruton's tyrosine kinase (Btk) irreversible inhibitor.PCI-32765 (Ibrutinib) is a selective and irreversible pyrrolopyrimidine-based inhibitor of BTK with IC50 of 0.5 nM. [1] PCI-32765 binds irreversibly to Cys-481 in BTK and thus is only active with other kinases with such a modifiable cysteine residue. In DOHH2 cells, in which the BCR pathway can be activated by anti-IgG, PCI-32765 inhibits autophosphorylation of BTK (IC50, 11 nM), BTK's physiological substrate, PLCg (IC50, 29 nm), and downstream ERK (IC50, 13 nm).
Ibrutinib is a high potent irreversible BTK inhibitor with an IC50 of 0.46 nM for the purified Btk.PCI-32765 (Ibrutinib) is highly active and well tolerated in CLL/SLL pts irrespective of high risk genomic abnormalities. Although follow-up is short, the high response rate and very low progression rate suggests that PCI-32765 (Ibrutinib) may be an important new targeted treatment approach for CLL pts. In ex vivo assays with whole bold, PCI-32765 (Ibrutinib) prevents the activation of human BCR with an IC50 of about 0.2 μM, while not influencing the activation of T cell. Treatment of CD40 or BCR activated CLL cells with PCI-32765 (Ibrutinib) results in inhibition of BTK tyrosine phosphorylation and also effectively abrogates downstream survival pathways activated by this kinase including ERK1/2, PI3K, and NF-κB. In addition, PCI-32765 (Ibrutinib) prevents activation-induced proliferation of CLL cells in vitro, and effectively inhibits survival signals provided externally to CLL cells from the microenvironment including soluble factors (CD40L, BAFF, IL-6, IL-4, and TNF-α), fibronectin engagement, and stromal cell contact. PCI-32765 is originally developed by Pharmacyclics. And participants is been invited for the phase I clinical trials.
Ibrutinib is an active pharmaceutical ingredient used for antineoplastics.
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Package
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1kg/bag ,25kg/bag;25kg/drum; customize as customer's equirements.
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Transit
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Fedex, TNT,DHL,EMS,and so on.
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Shipping port
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Shanghai/Tianjin/Dalian/Beijing/Xi'an
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Lead Time
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1-2 working days upon received the payment
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For mass orders, it will be delivered by air or sea. Depending on your location, please allow 1-5 business days for your order to arrive. For small order, please expect 3-7 days by UPS DHL EMS. For mass order, please allow 5-8 days by Air, 15-30 days by Sea. |
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Service:
1. Any inquiries will be replied within 12 hours.
2. Dedication to quality, supply & service.
3. Strictly on selecting raw materials.
4. OEM/ODM Available.
5. Reasonable & competitive price, fast lead time.
6. Sample is available for your evaluation & formulation development.
Advantages:
1. Faster delivery: Sample order in stock and 3-7 days for bulk production.
2. We have strong cooperation with DHL, TNT, UPS, FEDEX, EMS. Or you also can choose your own shipping forwarder.
3. After-Sale Service:
1)International Authorized Third-Party Test For The Products You Demand.
2)60 Days Warranty of quality of goods.
Hefei JOYE Import & Export CO.,LTD is a import and export trade company established in 2011.Approved by the Chinese government set up trade enterprises.The Customs Registration code of the company is 3401961603.
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Audited Supplier 
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